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Stem Cell-Based Human Blood–Brain Barrier Models for Drug Discovery and Delivery

Abstract : The development of novel neuropharmaceuticals requires the evaluation of blood-brain barrier (BBB) permeability and toxicity. Recent studies have highlighted differences in the BBB among different species, with the most important differences involving the expression of P-glycoprotein (P-gp), multidrug resistance-associated proteins, transporters, and claudins. In addition, functional studies have shown that brain pharmacokinetics of P-glycoprotein substrates are different in humans and rodents. Therefore, human BBB models may be an important platform for initial drug screening before in vivo studies. This strategy might help to reduce costs in drug development and failures in clinical studies. We review the differences in the BBB among species, recent advances in the generation of human BBB models, and their applications in drug discovery and delivery.
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Submitted on : Tuesday, March 17, 2020 - 4:15:23 PM
Last modification on : Wednesday, March 25, 2020 - 3:43:21 PM

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S. Aday, R. Cecchelli, D. Hallier-Vanuxeem, M.P. Dehouck, L. Ferreira. Stem Cell-Based Human Blood–Brain Barrier Models for Drug Discovery and Delivery. Trends in Biotechnology, Elsevier, 2016, 34 (5), pp.382-393. ⟨10.1016/j.tibtech.2016.01.001⟩. ⟨hal-02510293⟩

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