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Journal Articles Journal of Neuroinflammation Year : 2021

Differential neurovirulence of Usutu virus lineages in mice and neuronal cells

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Sylvie Lecollinet
Cécile Beck

Abstract

Usutu virus (USUV) is an emerging neurotropic arthropod-borne virus recently involved in massive die offs of wild birds predominantly reported in Europe. Although primarily asymptomatic or presenting mild clinical signs, humans infected by USUV can develop neuroinvasive pathologies (including encephalitis and meningoencephalitis). Similar to other flaviviruses, such as West Nile virus, USUV is capable of reaching the central nervous system. However, the neuropathogenesis of USUV is still poorly understood, and the virulence of the specific USUV lineages is currently unknown. One of the major complexities of the study of USUV pathogenesis is the presence of a great diversity of lineages circulating at the same time and in the same location.
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Dates and versions

hal-03126852 , version 1 (03-02-2021)

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Attribution - CC BY 4.0

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Marion Clé, Orianne Constant, Jonathan Barthelemy, Caroline Desmetz, Marie France Martin, et al.. Differential neurovirulence of Usutu virus lineages in mice and neuronal cells. Journal of Neuroinflammation, 2021, 18 (1), pp.11. ⟨10.1186/s12974-020-02060-4⟩. ⟨hal-03126852⟩
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