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Endothelial calcium dynamics, connexin channels and blood–brain barrier function

Abstract : Situated between the circulation and the brain, the blood-brain barrier (BBB) protects the brain from circulating toxins while securing a specialized environment for neuro-glial signaling. BBB capillary endothelial cells exhibit low transcytotic activity and a tight, junctional network that, aided by the cytoskeleton, restricts paracellular permeability. The latter is subject of extensive research as it relates to neuropathology, edema and inflammation. A key determinant in regulating paracellular permeability is the endothelial cytoplasmic Ca(2+) concentration ([Ca(2+)]i) that affects junctional and cytoskeletal proteins. Ca(2+) signals are not one-time events restricted to a single cell but often appear as oscillatory [Ca(2+)]i changes that may propagate between cells as intercellular Ca(2+) waves. The effect of Ca(2+) oscillations/waves on BBB function is largely unknown and we here review current evidence on how [Ca(2+)]i dynamics influence BBB permeability.
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Submitted on : Monday, March 23, 2020 - 3:13:59 PM
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Marijke de Bock, Nan Wang, Elke Decrock, Mélissa Bol, Ashish Gadicherla, et al.. Endothelial calcium dynamics, connexin channels and blood–brain barrier function. Progress in Neurobiology, 2013, 108, pp.1-20. ⟨10.1016/j.pneurobio.2013.06.001⟩. ⟨hal-02515498⟩



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