Skip to Main content Skip to Navigation
Journal articles

Oxysterols and the NeuroVascular Unit (NVU): A far true love with bright and dark sides

Abstract : The brain is isolated from the whole body by the blood-brain barrier (BBB) which is located in brain microvessel endothelial cells (ECs). Through physical and metabolic properties induced by brain pericytes, astrocytes and neurons (these cells and the ECs referred to as the neurovascular unit (NVU)), the BBB hardly restricts exchanges of molecules between the brain and the bloodstream. Among them, cholesterol exchanges between these two compartments are very limited and occur through the transport of LDLs across the BBB. Oxysterols (mainly 24S and 27-hydroxycholesterol) daily cross the BBB and regulate molecule/cholesterol exchanges via Liver X nuclear Receptors (LXRs). In addition, these oxysterols have been linked to pathological processes in neurodegenerative diseases such as Alzheimer's disease. Here we propose an overview of the actual knowledge concerning oxysterols and the NVU cells in physiological and in Alzheimer's disease.
Document type :
Journal articles
Complete list of metadata

https://hal-univ-artois.archives-ouvertes.fr/hal-02505516
Contributor : Accord Elsevier CCSD Connect in order to contact the contributor
Submitted on : Friday, October 22, 2021 - 9:15:22 PM
Last modification on : Wednesday, November 3, 2021 - 6:12:51 AM
Long-term archiving on: : Monday, January 24, 2022 - 5:08:25 PM

File

S0960076019301724.pdf
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution - NonCommercial 4.0 International License

Identifiers

Collections

Citation

Julien Saint-Pol, Fabien Gosselet. Oxysterols and the NeuroVascular Unit (NVU): A far true love with bright and dark sides. Journal of Steroid Biochemistry and Molecular Biology, Elsevier, 2019, 191 (105368), ⟨10.1016/j.jsbmb.2019.04.017⟩. ⟨hal-02505516⟩

Share

Metrics

Record views

16

Files downloads

17