Viral neuraminidase and cellular ectosialyltransferase in human lymphoblastoid cells infected with influenza virus

Abstract : In human lymphoblastoid cells, infected with an influenza virus, Fowl Plague Virus (FPV), glycoproteins (such as secreted IgM) are hyposialylated, through the action of viral neuraminidase. In this study, the modulation of the cellular ectosialyltransferase activity during viral infection was investigated. This activity was detectable in FPV-infected cells, was shown to be 2.5-fold higher than that of uninfected cells, and to be able to restore, at least partially, the level of sialylation of the cell surface acceptors.
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Submitted on : Monday, December 13, 2010 - 1:01:43 PM
Last modification on : Monday, September 23, 2019 - 3:32:04 PM

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Madeleine Duc Dodon, Roméo Cecchelli, René Cacan, Louis Gazzolo, André Verbert. Viral neuraminidase and cellular ectosialyltransferase in human lymphoblastoid cells infected with influenza virus. Biochimie, Elsevier, 1984, 66, p. 493-496. ⟨hal-00545953⟩

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