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Journal articles
Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: An in vitro study
Abstract : NXY-059, a polar compound with limited transport across the blood-brain barrier, has demonstrated neuroprotection in several animal models of acute ischemic stroke but failed to confirm clinical benefit in the second phase III trial (SAINT-II). To improve the understanding of the mechanisms responsible for its neuroprotective action in preclinical models a series of experiments was carried out in an in vitro blood-brain barrier (BBB) model. A clinically attainable concentration of 250 μmol/L of NXY-059 administered at the onset or up to 4 h after oxygen glucose deprivation (OGD) produced a significant reduction in the increased BBB permeability caused by OGD. Furthermore, OGD produced a huge influx of tissue plasminogen activator across the BBB, which was substantially reduced by NXY-059. This study suggests that the neuroprotective effects of NXY-059 preclinically, may at least in part be attributed to its ability to restore functionality of the brain endothelium.
https://hal-univ-artois.archives-ouvertes.fr/hal-00544037
Contributor : Wilfried Déplanques <>
Submitted on : Tuesday, December 7, 2010 - 10:55:02 AM
Last modification on : Wednesday, March 25, 2020 - 3:43:16 PM
Contributor : Wilfried Déplanques <>
Submitted on : Tuesday, December 7, 2010 - 10:55:02 AM
Last modification on : Wednesday, March 25, 2020 - 3:43:16 PM
