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Modélisation in vitro de la barrière hémato-encéphalique

Abstract : The blood-barrier (BBB) is located at the brain microvessel level and isolates the brain from the whole body, thus restricting molecule and cell exchanges between cerebral and peripheral compartments. In order to better decipher and understand the BBB physiology and development, and to investigate transport mechanism and toxicity of neuropharmaceuticals, several in vitro BBB models have been developed using animal or human cells, primary or immortalized cells. The aim of this review to explain to the reader the major criteria required for a pertinent in vitro BBB model and to briefly expose the different models currently available with their characteristics with a special focus on the static models.
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Contributor : Wilfried Déplanques Connect in order to contact the contributor
Submitted on : Monday, July 19, 2021 - 2:49:41 PM
Last modification on : Wednesday, July 21, 2021 - 8:38:46 AM


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Fabien Gosselet. Modélisation in vitro de la barrière hémato-encéphalique. médecine/sciences, EDP Sciences, 2017, 33 (4), pp.423-431. ⟨10.1051/medsci/20173304013⟩. ⟨hal-00543630⟩



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