How cyclodextrins can mask their toxic effect on the blood-brain barrier

Abstract : The toxicity of monosubstituted n-alkyldimethylammonium-β-cyclodextrins (DMA-Cn-CD with n = 2, 4 and 12) towards endothelial cells of an in vitro model of the blood-brain barrier (BBB) was evaluated and compared to that of the native β-CD. DMA-C12-CD was found to be non-toxic below 10 mM due to the self-inclusion of the alkyl chain in the CD cavity. A high percentage of passage (30%) of DMA-C12-CD through the endothelial cells has been measured.
Type de document :
Article dans une revue
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2006, 16 (7), p. 1784-1787
Liste complète des métadonnées

https://hal-univ-artois.archives-ouvertes.fr/hal-00543314
Contributeur : Wilfried Déplanques <>
Soumis le : lundi 6 décembre 2010 - 13:05:44
Dernière modification le : lundi 19 février 2018 - 09:26:02

Identifiants

  • HAL Id : hal-00543314, version 1

Collections

Citation

Céline Binkowski-Machut, Frédéric Hapiot, Patrick Martin, Roméo Cecchelli, Eric Monflier. How cyclodextrins can mask their toxic effect on the blood-brain barrier. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2006, 16 (7), p. 1784-1787. 〈hal-00543314〉

Partager

Métriques

Consultations de la notice

148