How cyclodextrins can mask their toxic effect on the blood-brain barrier

Abstract : The toxicity of monosubstituted n-alkyldimethylammonium-β-cyclodextrins (DMA-Cn-CD with n = 2, 4 and 12) towards endothelial cells of an in vitro model of the blood-brain barrier (BBB) was evaluated and compared to that of the native β-CD. DMA-C12-CD was found to be non-toxic below 10 mM due to the self-inclusion of the alkyl chain in the CD cavity. A high percentage of passage (30%) of DMA-C12-CD through the endothelial cells has been measured.
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Submitted on : Monday, December 6, 2010 - 1:05:44 PM
Last modification on : Thursday, February 21, 2019 - 10:34:05 AM

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Céline Binkowski-Machut, Frédéric Hapiot, Patrick Martin, Roméo Cecchelli, Eric Monflier. How cyclodextrins can mask their toxic effect on the blood-brain barrier. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2006, 16 (7), p. 1784-1787. ⟨hal-00543314⟩

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