Structural determination of the novel fragmentation routes of morphine opiate receptor antagonists using electrospray ionization quadrupole time-of-flight tandem mass spectrometry

Nicolas Joly; Anas El Aneed; Patrick Martin; Roméo Cecchelli; Joseph Banoub

Structural determination of the novel fragmentation routes of morphine opiate receptor antagonists using electrospray ionization quadrupole time-of-flight tandem mass spectrometry

Nicolas Joly ¹ Anas El Aneed Patrick Martin ¹ Roméo Cecchelli ¹ Joseph Banoub

1 LBHE - Laboratoire de Physiopathologie de la Barrière Hémato-Encéphalique

Abstract : Electrospray ionization quadrupole time-of-flight (ESI-QqToF) mass spectra of naltrindole hydrochloride 1, naltriben mesylate 2, and naltrexone hydrochloride 3, a common series of morphine opiate receptor antagonists, were recorded using different declustering potentials. Low-energy collision-induced dissociation (CID) MS/MS experiments established the fragmentation routes of these compounds. In addition, re-confirmation of the various established fragmentation routes was effected by conducting a series of ESI-CID-QqTof-MS/MS experiments using non-conventional quasi MSⁿ (up to MS⁸) product ion scans, which were initiated by CID in the atmospheric pressure/vacuum interface using a higher declustering potential. Precursor ion scan analyses were also performed with a conventional quadrupole-hexapole-quadrupole tandem mass spectrometer and allowed the confirmation of the genesis of some diagnostic ions.

Type de document :

Article dans une revue

Rapid Communications in Mass Spectrometry, Wiley, 2005, 19, p. 3119-3130

Domaine :

Sciences du Vivant [q-bio] / Biochimie, Biologie Moléculaire

Liste complète des métadonnées

https://hal-univ-artois.archives-ouvertes.fr/hal-00543171
Contributeur : Wilfried Déplanques <>
Soumis le : lundi 6 décembre 2010 - 09:24:25
Dernière modification le : lundi 6 décembre 2010 - 09:24:25

Structural determination of the novel fragmentation routes of morphine opiate receptor antagonists using electrospray ionization quadrupole time-of-flight tandem mass spectrometry

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Structural determination of the novel fragmentation routes of morphine opiate receptor antagonists using electrospray ionization quadrupole time-of-flight tandem mass spectrometry

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