Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, Epiciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Structural determination of the novel fragmentation routes of morphine opiate receptor antagonists using electrospray ionization quadrupole time-of-flight tandem mass spectrometry

Abstract : Electrospray ionization quadrupole time-of-flight (ESI-QqToF) mass spectra of naltrindole hydrochloride 1, naltriben mesylate 2, and naltrexone hydrochloride 3, a common series of morphine opiate receptor antagonists, were recorded using different declustering potentials. Low-energy collision-induced dissociation (CID) MS/MS experiments established the fragmentation routes of these compounds. In addition, re-confirmation of the various established fragmentation routes was effected by conducting a series of ESI-CID-QqTof-MS/MS experiments using non-conventional quasi MSn (up to MS8) product ion scans, which were initiated by CID in the atmospheric pressure/vacuum interface using a higher declustering potential. Precursor ion scan analyses were also performed with a conventional quadrupole-hexapole-quadrupole tandem mass spectrometer and allowed the confirmation of the genesis of some diagnostic ions.
Document type :
Journal articles
Complete list of metadata

https://hal-univ-artois.archives-ouvertes.fr/hal-00543171
Contributor : Wilfried Déplanques Connect in order to contact the contributor
Submitted on : Monday, December 6, 2010 - 9:24:25 AM
Last modification on : Friday, January 21, 2022 - 3:31:54 AM

Identifiers

  • HAL Id : hal-00543171, version 1

Collections

Citation

Nicolas Joly, Anas El Aneed, Patrick Martin, Roméo Cecchelli, Joseph Banoub. Structural determination of the novel fragmentation routes of morphine opiate receptor antagonists using electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid Communications in Mass Spectrometry, Wiley, 2005, 19, p. 3119-3130. ⟨hal-00543171⟩

Share

Metrics

Record views

34