Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, Epiciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Down-regulation of caveolin-1 in glioma vasculature: modulation by radiotherapy

Abstract : Primary brain tumors, particularly glioblastomas (GB), remain a challenge for oncology. An element of the malignant brain tumors' aggressive behavior is the fact that GB are among the most densely vascularized tumors. To determine some of the molecular regulations occuring at the brain tumor endothelium level during tumoral progression would be an asset in understanding brain tumor biology. Caveolin-1 is an essential structural constituent of caveolae that has been implicated in mitogenic signaling, oncogenesis, and angiogenesis. In this work we investigated regulation of caveolin-1 expression in brain endothelial cells (ECs) under angiogenic conditions. In vitro, brain EC caveolin-1 is down-regulated by angiogenic factors treament and by hypoxia. Coculture of brain ECs with tumoral cells induced a similar downregulation. In addition, activation of the p42/44 MAP kinase is demonstrated. By using an in vivo brain tumor model, we purified ECs from gliomas as well as from normal brain to investigate possible regulation of caveolin-1 expression in tumoral brain vasculature. We show that caveolin-1 expression is strikingly down-regulated in glioma ECs, whereas an increase of phosphorylated caveolin-1 is observed. Whole-brain radiation treatment, a classical way in which GB is currently being treated, resulted in increased caveolin-1 expression in tumor isolated ECs. The level of tumor cells spreading around newly formed blood vessels was also elevated. The regulation of caveolin-1 expression in tumoral ECs may reflect the tumoral vasculature state and correlates with angiogenesis kinetics.
Document type :
Journal articles
Complete list of metadata
Contributor : Wilfried Déplanques Connect in order to contact the contributor
Submitted on : Friday, November 19, 2010 - 3:40:31 PM
Last modification on : Friday, January 21, 2022 - 3:31:54 AM


  • HAL Id : hal-00537871, version 1



Anthony Régina, Julie Jodoin, Paul Khoueir, yannève Rolland, France Berthelet, et al.. Down-regulation of caveolin-1 in glioma vasculature: modulation by radiotherapy. Journal of Neuroscience Research, Wiley, 2004, 75, p. 291-299. ⟨hal-00537871⟩



Record views