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Personality dimensions of patients can change during the course of parkinson’s disease

Mathilde Boussac 1, * Christophe Arbus 2 Julia Dupouy 3 Estelle Harroch 2 Vanessa Rousseau 2 Aurélie Croiset 4 Fabienne Ory-Magne 2 Olivier J. Rascol 2 Caroline Moreau 5, 6 Anne-Sophie Rolland 5, 6 David Maltête 7 Tiphaine Rouaud 8 Mylène Meyer 9 Sophie Drapier 10, 11 Bruno Giordana 12 Mathieu Anheim 13 Elodie Hainque 14 Bechir Jarraya 15 Isabelle Benatru 16 Nicolas Auzou 17 Lhaouas Belamri 18 Mélissa Tir 19, 20 Ana Marques 21 Stéphane Thobois 22 Alexandre Eusebio 23 Jean Christophe Corvol 14 David Devos 5, 6 Christine Brefel-Courbon 2
Abstract : Background - Studies assessing personality dimensions by the "Temperament and Character Inventory" (TCI) have previously found an association between Parkinson's disease (PD) and lower Novelty Seeking and higher Harm Avoidance scores. Here, we aimed to describe personality dimensions of PD patients with motor fluctuations and compare them to a normative population and other PD populations. Methods - All PD patients awaiting Deep Brain Stimulation (DBS) answered the TCI before neurosurgery. Their results were compared to those of historical cohorts (a French normative population, a de novo PD population, and a PD population with motor fluctuations). Results - Most personality dimensions of our 333 included PD patients with motor fluctuations who are candidates for DBS were different from those of the normative population and some were also different from those of the De Novo PD population, whereas they were similar to those of another population of PD patients with motor fluctuations. Conclusions - During the course of PD, personality dimensions can change in parallel with the development of motor fluctuations, either due to the evolution of the disease and/or dopaminergic treatments.
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Submitted on : Tuesday, February 2, 2021 - 2:02:35 PM
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Mathilde Boussac, Christophe Arbus, Julia Dupouy, Estelle Harroch, Vanessa Rousseau, et al.. Personality dimensions of patients can change during the course of parkinson’s disease. PLoS ONE, Public Library of Science, 2021, 16 (1), pp.e0245142. ⟨10.1371/journal.pone.0245142⟩. ⟨hal-03128733⟩

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