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Short H2A histone variants are expressed in cancer

Abstract : Short H2A (sH2A) histone variants are primarily expressed in the testes of placental mammals. Their incorporation into chromatin is associated with nucleosome destabilization and modulation of alternate splicing. Here, we show that sH2As innately possess features similar to recurrent oncohistone mutations associated with nucleosome instability. Through analyses of existing cancer genomics datasets, we find aberrant sH2A upregulation in a broad array of cancers, which manifest splicing patterns consistent with global nucleosome destabilization. We posit that short H2As are a class of "ready-made" oncohistones, whose inappropriate expression contributes to chromatin dysfunction in cancer.
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Contributor : Antoine Molaro <>
Submitted on : Friday, January 22, 2021 - 4:42:15 PM
Last modification on : Thursday, February 25, 2021 - 6:44:02 PM
Long-term archiving on: : Friday, April 23, 2021 - 7:24:41 PM


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Guo-Liang Chew, Marie Bleakley, Robert Bradley, Harmit Malik, Steven Henikoff, et al.. Short H2A histone variants are expressed in cancer. Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.490. ⟨10.1038/s41467-020-20707-x⟩. ⟨hal-03118929⟩



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