Cryoablation for Palliation of Painful Bone Metastases: The MOTION Multicenter Study - Ecole Nationale du Génie de l'Eau et de l'Environnement de Strasbourg Accéder directement au contenu
Article Dans Une Revue Radiology: Imaging Cancer Année : 2021

Cryoablation for Palliation of Painful Bone Metastases: The MOTION Multicenter Study

Jack W. Jennings
  • Fonction : Auteur
J. D. Prologo
  • Fonction : Auteur
Xavier Buy
  • Fonction : Auteur
Jean Palussiere
  • Fonction : Auteur
A. Nicholas Kurup
  • Fonction : Auteur
Matthew Callstrom
  • Fonction : Auteur
Scott Genshaft
  • Fonction : Auteur
Fereidoun Abtin
  • Fonction : Auteur
Ambrose J. Huang
  • Fonction : Auteur
Jason Iannuccilli
  • Fonction : Auteur
Frank Pilleul
  • Fonction : Auteur
Charles Mastier
  • Fonction : Auteur
Peter J. Littrup
  • Fonction : Auteur
Thierry de Baere
  • Fonction : Auteur
Frédéric Deschamps
  • Fonction : Auteur

Résumé

Purpose To assess the clinical effectiveness of cryoablation for palliation of painful bone metastases. Materials and Methods MOTION (Multicenter Study of Cryoablation for Palliation of Painful Bone Metastases) (ClinicalTrials.gov NCT 02511678) was a multicenter, prospective, single-arm study of adults with metastatic bone disease who were not candidates for or had not benefited from standard therapy, that took place from February 2016 to March 2018. At baseline, participants rated their pain using the Brief Pain Inventory-Short Form (reference range from 0 to 10 points); those with moderate to severe pain, who had at least one metastatic candidate tumor for ablation, were included. The primary effectiveness endpoint was change in pain score from baseline to week 8. Participants were followed for 24 weeks after treatment. Statistical analyses included descriptive statistics and logistic regression to evaluate changes in pain score over the postprocedure follow-up period. Results A total of 66 participants (mean age, 60.8 years ± 14.3 [standard deviation]; 35 [53.0%] men) were enrolled and received cryoablation; 65 completed follow-up. Mean change in pain score from baseline to week 8 was −2.61 points (95% CI: −3.45, −1.78). Mean pain scores improved by 2 points at week 1 and reached clinically meaningful levels (more than a 2-point decrease) after week 8; scores continued to improve throughout follow-up. Quality of life improved, opioid doses were stabilized, and functional status was maintained over 6 months. Serious adverse events occurred in three participants. Conclusion Cryoablation of metastatic bone tumors provided rapid and durable pain palliation, improved quality of life, and offered an alternative to opioids for pain control.
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Dates et versions

hal-03968866 , version 1 (01-02-2023)

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Jack W. Jennings, J. D. Prologo, Julien Garnon, Afshin Gangi, Xavier Buy, et al.. Cryoablation for Palliation of Painful Bone Metastases: The MOTION Multicenter Study. Radiology: Imaging Cancer, 2021, 3 (2), ⟨10.1148/rycan.2021200101⟩. ⟨hal-03968866⟩
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