HIV-mediated immune aging in young adults infected perinatally or during childhood - Centre de recherche en Épidémiologie et Santé des Populations Accéder directement au contenu
Article Dans Une Revue AIDS. Official journal of the international AIDS Society Année : 2019

HIV-mediated immune aging in young adults infected perinatally or during childhood

Résumé

BACKGROUND: HIV-infected patients progressing towards disease present a premature immune aging profile, characterized by the exhaustion of lymphopoiesis. The development of these anomalies may be prevented in young HIV-infected patients owing to their robust immune resources and lymphocyte regeneration capacities. METHODS: An immunomonitoring substudy was designed for young adults aged between 18 and 25 years, living with HIV since childhood included in the national ANRS Co19 COVERTE Cohort. We compared markers associated with immune aging, including the frequency of circulating hematopoietic progenitors and the phenotype of lymphocyte populations, with those of patients infected with HIV in adulthood. RESULTS: HIV-infected young adults displayed decreasing numbers of CD34 hematopoietic progenitors and mature lymphocytes, indicative of general lymphopenia and reminiscent of the alterations found in patients infected in adulthood or uninfected elderly people. This highlights the strong impact of HIV on the immune system despite patient's young age at infection. Immune aging-related alterations were particularly obvious in young patients who presented high viral loads. CONCLUSION: HIV-infected young adults can present increased markers of immune activation and senescence, related to uncontrolled viral replication. This highlights the issue of noncompliance to antiretroviral therapy in patients at a young age, resulting in loss of viral control, premature immunosenescence, and potentially irreversible damage of their lymphopoietic system.
Fichier principal
Vignette du fichier
Fastenackels et al. - 2019 - HIV-mediated immune aging in young adults infected.pdf (1.48 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02446214 , version 1 (20-01-2020)

Identifiants

Citer

Solène Fastenackels, Delphine Sauce, Corinne Vigouroux, Véronique Avettand-Fenoel, Jean-Philippe Bastard, et al.. HIV-mediated immune aging in young adults infected perinatally or during childhood. AIDS. Official journal of the international AIDS Society, 2019, 33 (11), pp.1705-1710. ⟨10.1097/QAD.0000000000002275⟩. ⟨hal-02446214⟩
210 Consultations
233 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More